Cytotoxicity of TNT and its metabolites.

نویسندگان

  • H. N. Banerjee
  • M. Verma
  • L. H. Hou
  • M. Ashraf
  • S. K. Dutta
چکیده

The production and storage of explosives has resulted in the environmental accumulation of 2,4,6-trinitrotoluene (TNT). The biotransformation products of the nitroaromatic compound TNT and metabolites in mammalian cells in culture and their cytotoxicity are studied. We report after our analysis by reverse phase high performance liquid chromatography (HPLC) that the most prevalent biotransformation product of TNT in the NG108 neuroblastoma cells is primarily monoamino-dinitrotoluene (2Am-DNT). It causes toxic effects based on trypan blue exclusion and LDH-release colorimetric assays.

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عنوان ژورنال:
  • The Yale Journal of Biology and Medicine

دوره 72  شماره 

صفحات  -

تاریخ انتشار 1999